Polymerase Chain Reaction in Haematological Malignancies

The polymerase chain reaction (PCR) has rapidly become an invaluable technique for the detection, molecular characterization and clinical management of a wide variety of Haematological disorders. PCR provides a rapid method for the generation of large quantities of relatively pure DNA sequences of interest. Two out of every five patients were diagnosed following an emergency admission, and this was associated with advanced disease and poor survival (p < 0.001). Among the 80% of patients treated with curative chemotherapy, survival discrepancies emerged at the point of diagnosis; the adjusted hazard ratio (emergency versus non-emergency) at one month being 4.0 (95% confidence interval 1.9–8.2). No lasting impact was evident in patients who survived for 12 months or more.

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