Climate Changes in the Microenvironment of Chronic Lymphocytic Leukaemia

Despite ongoing efforts to decipher the cancer genome, discoveries of new targetable genetic lesions within cancer cells are rare. Therefore, alternative approaches are needed. Signals from the microenvironment are increasingly recognized as drivers of disease progression in hematologic and solid cancers. Consequently, there is growing interest in targeting the tumor-microenvironment cross-talk. This review highlights recent therapeutic advances in targeting the microenvironment in chronic lymphocytic leukemia (CLL). The number of new cases of chronic lymphocytic leukemia was 4.7 per 100,000 men and women per year. The number of deaths was 1.3 per 100,000 men and women per year. These rates are age-adjusted and based on 2012-2017 cases and deaths.

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